The new anticancer agent produced by interaction of the complex trans-dichlorodiamminplatinum(II) with arabinogalactan and its properties
Alexander Konstantinovich Starkov, Galina Anatolievna Kozuchovskaya, Nina Ivanovna Pavlenko
Abstract
The obtained new product of reaction of the complex trans-dichlorodiaminplatinum(II) with arabinogalactan was characterized by XRD, IR-spectroscopy, UF-spetrophotometry and thermogravimetry. The composition and structure of this product was studied. It has been shown that trans-dichlorodiaminplatinum(II) associated with arabinogalactan through communications –C-O-C- amino hydrogen of the original complex.
The synthesized product has the new pharmacological properties. This agent is more soluble, less toxic and shows a greater anticancer activity as compared to cis-dichlorodiaminplatinum(II).