The sulfide sorbents based on MCM-41 have been synthesized. The chemical and thermal stability of sorbents obtained have been investigated by physicochemical methods. It has been found that the acid treatment of the samples at boiling point results in insignificant changes in structural, textural and sorption characteristics, demonstrating total losses of sorbent to 15 wt%, that, in our opinion, concerned with the dissolution of malformed and unstructured particles of silica matrix. The neutral and ammonium treatment excites more significant changes concerned with starting the matrix dissolution (weight loss is about 25-30 wt%). Nevertheless, the grafted organic functional layer is saved. The sorbents obtained are quite stable in studied aggressive media and able to work over a long period of time in a variety of technological solutions and are not inferior to well-known commercial sorbents with functional groups.