The authors attempt to disclose the specifics of the adaptation of the Altai region to external challenges and threats specific to different stages of economic development. The source is characterized by the level of socio-economic development of the region on the eve of market reforms. Peculiar contradictions of regional reproduction process. These factors contributing to the cumulative effect of the decline of the regional economy. The evaluation of the status of intra-regional environments at the stages of transformational crisis (1992-1998), recovery growth (1999-2007), the crisis of 2008-2009, out of the crisis (2010-2012) and the structural crisis of the economy (2013-2016).

The conclusion is made about the coincidence of the key trends of socio-economic development of the Altai Region and Russia. The features of the development of the region and contributing to their causes. The authors formulated a number of conclusions of a conceptual nature for the formation of scientific bases of strategy of development of region for the period until 2035.