Russian security and economic interests in the post-soviet republics in the Caucasian-Caspian and Central Asia regions are affected by the strategy of all “big players”. The USA and the UK used Kazakhstan to undermine Russian interests by opening of a new "international financial center” - an offshore haven for islamic banking aimed to attract Russian capital and to promote centrifugal tendencies in other Muslim republics. China as a rising global economic power is expanding its influence in all post-soviet republics. However, it needs not only Russian energy and natural resources but also Russia’s role as a vital territorial bridge between Asia and Europe. In cooperation with China Uzbekhistan opened a new economic think-tank center aimed at expanding of multilateral economic cooperation. However, these activities are coordinated with Russia in order to keep a balance in bilateral relations. Russia is counter-acting all centrifugal trends in the region by using bilateral and multilateral diplomacy. Increase of international cooperation worldwide.