The preliminary results of an interdisciplinary study of the basic socio-economic and socio-cultural factors necessary for a correct and comprehensive assessment of human capital at the level of individual territories of the macro region Yenisei Siberia are presented. The parameters of socio-economic and socio-cultural development for individual territories of the macro-region Yenisei Siberia were analyzed using the methods of index and statistical evaluation. Estimates of the significance of the effects of the diversity of society in the context of inter-regional comparisons and dynamic changes are made. A comparison of the results obtained at different levels of the hierarchy. The considered socio-economic indicators and socio-cultural factors are analyzed from the standpoint of their influence on the level, dynamics and quality of human capital. The study was carried out with the financial support of the Russian Foundation for Basic Research, the Government of the Krasnoyarsk Territory, the Krasnoyarsk Regional Fund of Science in the framework of the research project “Formal Approaches and Practices for Measuring Human Capital in the Context of Assessing the Quality of Life of the Territory’s Population (Yenisei Siberia)” №: 18-410-242006  (r_mk).