In accordance with the legislation of the Russian Federation on countering corruption, educational organizations are obliged to take measures to prevent corruption. At the same time, the content, forms, methods and subjects of the organization of anti-corruption preventive work are questions that do not have a definite answer. Siberian Federal University implements a set of measures to prevent corruption based on its own scientific findings. Long-term preventive activity predetermined the institutionalization of relations in corruption prevention at the University. Specialized structural units for corruption prevention established under local regulatory acts in connection with the increasing complexity of the tasks and emerging needs successfully operate. The corruption prevention program annually adopted in Siberian Federal University lays out the specifics of the main directions of work. At the same time, one of the important areas implemented by the organization is the anti-corruption enlightenment of students and employees, as well as ensuring the information transparency of corruption prevention. In the absence of a proper scientific and methodological basis for corruption prevention in educational institutions of higher education, the experience of Siberian Federal University may be useful to other educational organizations of various types.