The administration of science and innovations is one of the most actively studied areas of knowledge in modern research in the field of management. The article concentrates on an overview of the existing practices of the organisations supporting science, research and development, and innovations in the regions of the Russian Federation. At present, in developed countries all over the world, high-tech product exports tend to occupy a substantial share in the country economics. The costs of R&D have a significant contribution to the value of such products. Consequently, the creation of high-tech products is directly related to the proper functioning of the research and innovation sector, which is impossible without a well-built system of research and innovations support organisations, both at the national and regional levels. The attraction of the research community to innovation activities through financial support leads to a significant increase in the scientific potential of regions and the state as a whole, which cannot but the most positively affect the economy. State support for innovations is a set of measures taken by state authorities of the Russian Federation and local administrative agencies in accordance with the national and local laws in order to create the necessary legal, economic and organisational environment; as well as the incentives for legal and physical entities who carry out innovation activities. The Strategy of Scientific and Technological Development of the Russian Federation specifies the organisations supporting science, R&D and innovations as an important element of the research and innovation system and one of the key elements of the Science National Project. Their effective operation is to facilitate the development of Russia and ensure the ability of the country and its regions to effectively meet major challenges. As part of the article, we analyse regional models of the science, R&D and innovation support organisations that are currently in force and those being proposed by Russian and foreign authors. We also evaluate the network cooperation of various types of regional support organisations with each other, taking into account the synergy effect. As a result, the most effective mechanisms and practices of the organisations supporting science, R&D and innovations at the regional level in the Russian Federation should be determined. In addition, we will define the goals of regional infrastructure elements of the research and innovations support organisations focused on the consumer in the innovation cycle. The data obtained in the research will contribute to the formation of an effective operation system and application of the best Russian and foreign practices by the existing science, R&D and innovations support organisations in the future.