Brassinosteroids-based biostimulants – “Epin” and “Epin-Extra” – recommended for treatment of various crops, as well as for use in floriculture and horticulture, have a wide range of stimulating and protective effects, which leads to increased yields and improved agricultural products. However, information on the effectiveness and expediency of using these preparations in conditions of environmental pollution with heavy metals and drought is insignificant and requires further study. The review article covers issues related to brassinosteroids, the derivatives of which are biostimulants “Epin” and “Epin-Extra”, and the possibilities of using them to protect plants from adverse factors, such as heavy metals and drought. Information related to the history of the discovery and study of brassinosteroids, their chemical nature, biosynthesis and metabolism, the mechanisms of action of brassinosteroids on the plant cell and the physiological effects resulting from this, as well as features of the interaction of brassinosteroids with other substances stimulating the growth and development of plants is presented. The issues of lead phytotoxicity, its effects on growth, development, productivity and plant resistance are considered. Based on the analysis of literary sources and own research, data on the protective action of brassinosteroids and preparations based on them on plants which growing in an environment with a high content of mobile lead are systematized. Literary and original data from own research concerning the adaptogenic effect that brassinosteroids and preparations based on them can have on plants under conditions of water stress or soil drought are discussed. The prospect of using the preparations “Epin” and “Epin-Extra” in plant growing with the aim of increasing the yield and quality of agricultural products in drought conditions is shown. Arguments in favor of further study of these biostimulants with the aim of specifying the application rules depending on the characteristics of the stress factor and the biological nature of the plant are given.