Solubility Study of Betulonic Acid in the Presence of Hydroxypropyl-γ-cyclodextrin by Capillary Electrophoresis
Viktoria Sursyakova
Abstract
Solubility of betulonic acid in 40 mM hydroxypropyl-γ-cyclodextrin solution was studied by capillary electrophoresis. It was shown that the equilibrium of complexation reaction between betulonic acid and hydroxypropyl-γ-cyclodextrin was established for three days. The oxidation of betulonic acid by atmospheric oxygen was shown not to occur during the long stirring. The solubility of betulonic acid in 40 mM aqueous cyclodextrin solution was 410±20 mg/l.