SYNTHESIS AND SULPHONYLATION OF 4-AMINO-3-METHOXYMETHYL-5-(4-CHLOROPHENYL)-1H-PYRAZOLE
Ilya G Povarov, Diana I Persidskaya, Victor V Efimov, Alexey V Lyubyashkin, Georgy A Suboch, Mikhail S Tovbis
Abstract
The paper presents experimental data on the preparation of 1-(4-chlorophenyl)-4-methoxy-1,2,3-butanetrione-2-oxime. Its cyclization with the formation of a new substituted nitrosopyrazole was carried out. In the first, 4-amino-3-methoxymethyl-5-(4-chlorophenyl)-1H-pyrazole was obtained and its sulfonylation with p-toluenesulfonyl chloride was carried out. The structure of all compounds is proved by means of IR, UV, NMR spectroscopy. It was found that 4-amino-3-methoxymethyl-5-(4-chlorophenyl)-1H-pyrazole in chloroform solution exists as a double ion.