Mechanochemical synthesis of cocrystals of betulin with adipic acid
Svetlana Anatolievna Myz, Mikhail Aleksandrovich Michailenko, Anastasiya Vitalievna Mikhailovskaya, Anatolii Aleksandrovich Politov, Kuznetsova Svetlana Alekseevna, Tatyana Petrovna Shakhtshneider
Abstract
The cocrystal of betulin with adipic acid was prepared using a liquid-assisted grinding method. The formation of cocrystal was confirmed by powder X-ray diffraction and IR spectroscopy methods. In order to choose a liquid for preparing cocrystal, solvents of different polarity were compared. It was shown that cocrystal of betulin with adipic acid was formed if solvents were used during mechanical treatment, in which the increased solubility of adipic acid was observed.