On the example of the onboard radio-electronic spacecraft's equipment creation are presented results of development and approbation of a technical and information solutions of "the electronic enterprise" of missile-space branch and the industry standard RD-134-0184-2010 "The methodical recommendations for implementation of information support technologies of the onboard radio-electronic equipment's creation of the missile and space engineering at all stages of life cycle" which includes recommendations about the organization of "the electronic enterprise" and to a choice program and hardware. Results of work are introduced in process of design of onboard radio-electronic spacecraft's equipment of the JSC "ISS" and allow to increase efficiency and competitiveness of the production, to reduce costs of purchase of program and technical providing, to reduce time of creation of onboard radio-electronic equipment of the missile and space engineering by 1,3 times, to reduce material expenses by 1,25 times.