The article deals with the innovative development of the regional economy, the rationale for the economic viability of biomedical technologies, and the importance of their development in Krasnoyarsk. The work analyzes the prerequisites for creation of a regional innovative biomedical cluster and identifies the necessary measures to support its effective development. To reduce the risks associated with the development of new biomedical technologies, it is proposed to use the approach recently adopted in developed countries, which is to perform evaluation at the early stages of the development of a medical technology. Using this approach will make it possible to forecast the demand for a new biomedical technology and the prospects for product sales in the market. If negative evaluation results are obtained, it becomes possible to abandon unprofitable projects or to change the development scenarios. The use of early assessment methods will optimize development costs and increase the investment attractiveness of the commercialization of new biomedical technologies.